Etopofos

Detaljerad miljöinformation

PEC is based on the following data;

A = 4,89 kg (data from Läkemedelsstatistik AB, LSAB).

PEC = 1,5 x 10^-4 x A = 1,5 x 10^-4 x 4,89 = 0,00073 μg/L

An aquatic PNEC can not be calculated due to lack of a full base set of ecotoxicology data. However, the extremely low PEC suggest little concern for environmental exposures and a screening PEC/PNEC calculation is based on the acute Daphnia NOEC.

PEC/PNEC = 0,00073 / 618 = 0,0000012

Ecotoxicological studies

Acute Daphnia NOEC = 618 000 μg/L (FDA 4.08, reference 1)

PNEC = NOEC / 1000 = 618 μg/L

Microorganisms

EC50 > 115 000 μg/L

NOEC = 25 000 μg/L (OECD 209, reference 2)

Degradation: no data

Metabolism

Etoposide is assumed to not undergo significant human metabolism. Excretion of the parent compound and its glucuronide conjugate is predominately via urine (reference 5).

Fate in Soil

Etoposide has low to moderate sorption to soil and sediments, with Koc values ranging from 181,1 to 308,5 (FDA 3.08, reference 3).

Bioaccumulation

Etoposide is a highly water soluble compound with low log Kow value of 1,03 to (FDA 3.02, reference 4).

References

1. ABC Laboratories Inc, Report No. 40,792, Acute Toxicity of Etoposide to Daphnia magna (FDA Technical Assistance Document 4.08), 1993.

2. ABC Laboratories Inc, Report No. 40,791Activated Sludge Respiration Inhibition Test with Etoposide (OECD 209), 1993.

3. ABC Laboratories Inc, Report No. 40,788, Soil/Sediment Adsorption-Desorption of 14C Etoposide (FDA Technical Assistance Document 3.08), 1993.

4. ABC Laboratories Inc, Report No. 40,784, Octanol/Water Partition Coefficient of Etoposide at 25ºC (FDA Technical Assistance Document 3.02), 1993.

5. Bristol-Myers Squibb Pharmaceutical Research Institute, Disposition of 14C-etoposide in cancer patients: a phase IV pharmacokinetic study, Report No. 50722, 1994.