Section 2: Psychological considerations

Considerations for psychiatric and neurocognitive impairment


Case presentation: Diagnosis of symptoms

Fictitious case. Case studies are representative only and individual responses may vary

CNS penetration effectiveness ranking


Larger numbers reflect estimates of better penetration or effectiveness in the central nervous system (eg, a ranking of 4 indicates the best penetration or effectiveness)

Letendre S, et al. Top HIV Med 2010;18:45–55

CPE score predicts CSF suppression & neuropsychosocial performance in some patients

¥ CPE scores (from 0 to 10) were correlated the scores with neuropsychological parameters * Sensitivity analysis indicated CPE ranking cut-off of 6 as highly predictive

1. Arendt G, et al. CROI 2011. Abstract 425 2. Antinori A, et al. CROI 2011. Poster 426

Neuropsychological considerations in older women with HIV

1. Wisniewski A, et al. J Neurovirol 2005;11:138–43;
2. Turner BJ, et al. J Gen Intern Med 2003;18:248–57;
3. Miller SA, et al. Menopause 2005;12:348–56 4. Fan M, et al. Menopause Int 2008;14:163–8; 5. Maki PM, et al. Neuropsychol Rev 2009;19:204–14