Higher rates of myocardial infarction and CVD risk factors in HIV-infected versus HIV-uninfected patients

Rates of myocardial infarction




Adapted from Triant VA. et al. J Clin Endocrin Metab 2007;92:2506–12







Are contributions from traditional risk factors the same in HIV?



HIV treatment risks

Adapted from Currier JS, et al. Circulation 2008;118:e29–e35







PIs/NNRTIs and Risk of MI: Cumulative exposure to each drug



Optimising treatment for naive patients

Adapted from Lundgren JD et al., CROI 2009; Abst 44LB








D:A:D: Percent of follow-up time at moderate and high CV risk after ever exposed to each of the drugs



optimising treatment for naive patients


Adapted from Lundgren JD et al., CROI 2009; Abst 44LB

*10 year predicted coronary heart disease risk (Framingham)









Exposure to PIs and risk of MI: ANRS



optimising treatment for naive patients



Adapted from Lang S, et al., 16th CROI, Montreal, Canada Feb 2009, Oral LB43








Recommendations for those at risk of cardiovascular disease




1.Gazzard B et al, HIV Med, 2008; 9:563–608
2.Molina J-M, et al. Lancet 2008;372:646–655