Section 3: Choosing a class


Factors to consider: treatment complexity


Factors to consider: resistance with first-generation NNRTIs

Case Mathias text1

1. Weinstock HS, et al. J Infect Dis 2004;189:2174-80.
2. Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents, 2006: http://AIDSinfo.nih.gov.
3. Wensing AM, et al. J Infect Dis 2005;192:958-66.
4. Novak RM, et al. Clin Infect Dis 2005;40:468-74.
5. Von Wyl V, et al. Arch Intern Med 2007;167:1782-90.


Factors to consider: genetic barrier to the development of resistance

Case Mathias graph4

1. Antinori A, et al. AIDS Res Hum Retroviruses 2002;18:835-8.
2. Lecossier D, et al. J Acquir Immune Defic Syndr 2005;38:37-42.
3. Vingerhoets J, et al. IV EHDRW, 2006.
4. Bertoli A, et al. IV EHDRW, 2006.
5. de Mendoza C, et al. HIV Clin Trials 2006;7:163-71.