Section 5: Management

Case studies are representative only and individual responses may vary


Didier re-presents after 6 months


Gastrointestinal disturbances: Grade 1–4 diarrhoea

case didier table 3

i-Base publications: How side effects are graded
Available at: http://www.i-base.info/guides/side/how.html (accessed April 2009)


Common reasons for discontinuation: tolerability

case didier graph 9

ATV/r-related diarrhoea in treatment-naïve patients at 96 weeks

  • Diarrhoea is one of the main reasons for poor HAART adherence
  • It is also one of the main reasons for HAART discontinuation
  • ATV/r is associated with fewer incidences of diarrhoea compared with LTV/r
case didier graph 10

Adapted from: 3. Molina JM, et al. ICAAC 2008, Abstract H-1250d


CASTLE: Mean change in overall IBS–QoL score from baseline to Week 24 in as-treated patients

case didier graph 11

Adapted from Su J, et al. XVII IAC, Mexico City, Mexico, 3-8 August 2008, Poster TUPE0060


Drug-related diarrhoea in treatment-naïve patients at 96 weeks

case didier graph 12

LPV/r QD is not approved in the EU. Data in figures are from different studies and cannot be compared directly. Adapted from: 1. Pulido F, et al. 47th ICAAC. Chicago, 17–20 Sept, 2007. Abstract H-361;
2. Mills A, et al. 48th ICAAC. Washington DC, Oct 25–28, 2008. Abstract H-1250c
3. Adapted from: 3. Molina JM, et al. ICAAC 2008, Abstract H-1250d


EZ Switch study: Better adherence and satisfaction with QD NRTI therapy

(Demonstrated by MEMS Caps)

case didier graph 13

**Taken within ±3 hours of prescribed interval.
Maitland D et al. HIV Medicine 2008;9:667-72


Pill counts for protease inhibitors in naive patients

case didier graph 16

Reyataz SmPC June 2008; Telzir SmPC December 2008; Kaletra SmPC November 2007;
Invirase SmPC October 2008; Prezista SmPC January 2008;


Didier’s prescription