Contraception and HIV treatment
- HIV infection continues to increase among women of childbearing age1
- HIV-infected women require contraceptive measures
- Effective dual contraceptive methods are required to avoid pregnancy and decrease risk of HIV transmission
- Potential drug–drug interactions must be considered
1. Finocchario-Kessler S, et al. AIDS Behav 2010;14:1106–14
What is effective contraception?
- Optimal contraceptive strategy involves use of condoms combined with an effective contraceptive method
- If half of all women using oral contraceptives also used condoms, an estimated 40% of unplanned pregnancies could be prevented1
- Physicians should discuss contraceptive options with the patient
- Women on ART should be advised to take double the dose of themorning-after pill levonorgestrel (2 x 1.5 mg)3
1. Pazol K, et al. Public Health Rep 2010;125:208–17
2. Heikinheimo O, et al. Hum Reprod Update 2009;15:165–76
3. Fakoya A, et al. HIV Med 2008;9;681–720
ARVs and oral contraceptives: Drug interactions
*EE = Ethinylestradiol; ‡ Co-administration with other hormonal/oral contraceptives containing progestogens other than norgestimate has not been studied, and therefore should be avoided. An alternate reliable method of contraception is recommended; ¥ Coadministration of FPV/r with oral contraceptives may increase the risk of hepatic transaminase elevations, alternative contraception methods are recommended; † For FPV/r and NFV alternative or additional contraceptive measures are recommended when administered with either EE- or norethindrone-containing hormonal contraceptives.
SmPCs. Available at http://www.ema.europa.eu Accessed March 2011
European oral contraceptives ≥30 µg EE
30 µg EE
>30 µg EE
SmPCs. Available at: http://www.medicines.org.uk/emc/. Accessed March 2011.