PK of ARVs during pregnancy

module3.2-section3-2

*Once-daily LPV/r dosing is not recommended during pregnancy because there are no data to address whether drug levels are adequate with such administration1 ARVs used during pregnancy should be selected only if potential benefit justifies the potential risk4

1. DHHS Perinatal guidelines. Available at http://aidsinfo.nih.gov/ContentFiles/PerinatalGL.pdf. Accessed March 2011; 2. Hardy H, et al. 1st International Workshop on HIV and Women, 2011. Poster 016;3. Best BM, et al. J Acquir Immune Defic Syndr 2010;54:381–8; 4. SmPCs. Available at http://www.ema.europa.eu Accessed March 2011


PK of ATV/r (300/100 mg and 400/100 mg) during pregnancy vs non-pregnant adults

module3.2-section3-3

ARVs used during pregnancy should be selected only if potential benefit justifies the potential risk2

1. Hardy H, et al. 1st International Workshop on HIV and Women, 2011. Poster 016;
2. SmPCs. Available at http://www.ema.europa.eu Accessed March 2011

module3.2-section3-4