Immune-related endocrinopathies1


  • YERVOY™ can cause inflammation of the endocrine system organs, specifically hypophysitis, hypopituitarism, adrenal insufficiency and hypothyroidism. Clinical experience with YERVOY™-associated endocrinopathy is limited
  • Monitor thyroid function tests, assess for signs and symptoms of endocrinopathies before each dose of YERVOY™
  • Patients should be advised to immediately report symptoms, such as headache, fatigue, visual field defect, behavioural changes and hypotension
  • Adrenal crisis as a cause of the patient’s symptoms must be excluded
  • Withhold YERVOY™ if pituitary imaging or laboratory tests of endocrine function are abnormal
  • Corticosteroid therapy and/or long-term hormonereplacement therapy may be necessary



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1. YERVOY™ Summary of Product Characteristics.

Senast uppdaterad:  2015-07-02Ansvarig:  Anna Labecker